DNA and RNA Extraction from FFPE Tissue

FormaPure XL Total

Extract DNA and RNA from the same formalin-fixed paraffin-embedded tissue sample using SPRI paramagnetic bead-based chemistry.

FormaPure XL reagent kits are available in multiple kit sizes and extraction types based on your application and throughput needs. For optimum convenience, you also receive knowledgeable support for reagents and automation methods from a single vendor.

  • Scalable, single-chemistry system compatible with manual and automated processing (including sample deparaffinization and lysis)
  • Simple workflow with minimal hands-on-time
  • Demonstrated flexibility to accommodate sample input variation
  • High performance for yield, integrity and purity has been shown
  • Performance demonstrated with a variety of sample and tissue types
  • Demonstrated performance with 7x 10 μM curls

Technical Documents:

Resources + Tools
Performance Data Liquid Handlers Support FAQs
FormaPure XL Total 核酸提取试剂盒

Explore From FFPE Tissue Models

FormaPure XL Total Visual Workflow

Genomics FormaPure Total XL Workflow

Product Specifications: FormaPure XL Total

Application Uses Nucleic Acid Sample Prep, Total NA Extraction, Total NA Isolation, Total NA Sequencing
Format Liquid
Starting Sample Material FFPE (formalin fixed paraffin embedded) tissue.
Automated Available Yes
Item Specifications Referenced C35991

Content and Resources

AMP 2019: Correlation between mutations found in FFPE tumor tissue and paired cfDNA samples In this poster, presented at AMP 2019, we present a comparison of matched FFPE and plasma samples to determine how many mutations are seen in both tissues. We also look at where the mutational mismatches appear in the chromosome.
Simultaneously DNA and RNA extraction from formalin-fixed paraffin embedded (FFPE) tissue In this poster we present a streamlined NGS ready to use sample prep workflow for FFPE tissue using a product in current development, FormaPure XL Total* (Beckman Coulter Life Science). FormaPure XL Total uses SPRI (Solid Phase Reverse Immobilization) paramagnetic beads to isolate DNA and RNA simultaneously.
Correlation between mutations found in FFPE tumor tissue and paired cfDNA samples In this poster we present a comparison of matched FFPE and plasma samples to determine how many mutations are seen in both tissues. We also look at where the mutational mismatches appear in the chromosome.
A complete workflow for high-throughput isolation of DNA and RNA from FFPE samples using Formapure XL Total on the KingFisher™ Sample Purification System This application note demonstrates the use of FormaPure XL Total, a total nucleic acid extraction kit for FFPE samples, in conjunction with the KingFisher™ Duo Prime Sample Purification System as a potential solution that mitigates some of the challenges with FFPE workflows.
Manual or Automated RNA, DNA or Total Nucleic Acid Extraction from FFPE Tissues FormaPure XL reagent kits represent a single-chemistry system with demonstrated capability for use in Next-Generation Sequencing (NGS) as well as other downstream applications including qPCR. Maximizing integrity, yield and purity from an FFPE sample is required to minimize the risk of losing important genetic information

Technical Documents

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